Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ SU1498
A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.
MilliporeSigma™ Calbiochem™ Rottlerin
Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ(IC50= 3-6μM) and PKCθ. Has about 10-fold lower potency against other isozymes.
MilliporeSigma™ Calbiochem™ D,L-Sulforaphane
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
MilliporeSigma™ Calbiochem™ Caspase-9 Substrate I, Fluorogenic
A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).
MilliporeSigma™ Calbiochem™ AP-1/NF-κB Dual Inhibitor, SP100030
A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC50 = 50
MilliporeSigma™ Calbiochem™ InSolution™ Lovastatin, Sodium Salt
Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.
MilliporeSigma™ Calbiochem™ InSolution™ Cyclopamine, V. californicum
The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Cypermethrin
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels.
MilliporeSigma™ Calbiochem™ Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (≈10 to 40 μM).
MilliporeSigma™ Calbiochem™ Histone Methyltransferase EZH2 Inhibitor, DZNep
Histone Methyltransferase EZH2 Inhibitor, DZNep, CAS 120964-45-6, is a cell-permeable inhibitor of EZH2-mediated trimethylation of K27 on histone H3.
MilliporeSigma™ Calbiochem™ InSolution™ Caspase-3 Inhibitor I, Cell-Permeable
The InSolution™ Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ 2',5'-Dideoxyadenosine
Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 μM), that binds to the adenosine P1 binding site.
MilliporeSigma™ Calbiochem™ Diclofenac Sodium
A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.
MilliporeSigma™ Calbiochem™ Dicoumarol
A cell-permeable quinone reductase inhibitor with anticoagulant properties.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor XVI
The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.